NEXIUM is a brand name of ‘esomeprazole magnesium’, a proton pump inhibitor which decreases the acid produced in the stomach.
Indications and uses:
Patients Buy NEXIUM online to treat various diseases and disorders as prescribed by their physician. The indicated uses are:
- Treating gastroesophageal reflux disease (GERD), which includes healing of erosive esophagitis and maintaining it
- Treating other conditions related to GERD like pathological hypersecretions including Zollinger-Ellison syndrome
- Treating heart burn and other symptoms associated with GERD
- Minimising the occurrence of gastric ulcers which may be associated with NSAID (non-steroidal anti-inflammatory drugs) therapy and
- Combination therapy of NEXIUM to treat H. pylori infections and reduce the risk of duodenal ulcer and its recurrence.
People purchase NEXIUM online and they get the drug in two forms: delayed-release capsules and delayed-release suspension. Both the formulations are administered orally. NEXIUM as delayed-release capsules is available in 20mg and 40 mg strength of esomeprazole magnesium trihydrate, in the form of enteric-coated granules. The inactive ingredients in the capsule are hypromellose, magnesium stearate, glyceryl monostearate 40-55, methacrylic acid copolymer type C, sugar spheres, talc, triethyl citrate and polysorbate 80.
NEXIUM as delayed –release oral suspension contains 2.5mg, 5mg, 10mg, 20mg and 40mg of esomeprazole in form of enteric coated granules which are similar to the granules used in capsules. The inactive ingredients used here are glycerol monostearate, crospovidone, iron oxide, xanthan gum, hydroxypropyl cellulose and dextrose.
Possible side effects of NEXIUM:
Patients can purchase NEXIUM online! However, they should understand the possible adverse reactions, which may be caused, due to it. The following side effects could be observed, due to administration of NEXIUM:
Fast and uneven heartbeats, dizziness, watery or bloody diarrhoea, cough and choking feeling, muscle weakness with cramps, jittery feeling, jerking muscle movements, and convulsions.
A patient may observe following general side effects like a headache, dry mouth, nausea, constipation, lack of hunger, stomach pain and flatulence.
Drug and food interactions with NEXIUM:
Patients buy NEXIUM online, as per their physician’s direction. However, they should disclose their other medications to him which are been taken, at the same time. This avoids any significant drug interactions if any.
Concomitant use of NEXIUM and antiretroviral drugs like nelfinavir, atazanavir or saquinavir should be avoided, as it may affect the absorption of antiviral drugs.
NEXIUM i.e. esomeprazole inhibits gastric acid production. Therefore drugs like atazanavir or ketokonazole for which pH plays an important role in absorption, are less absorbed.
Concurrent use of NEXIUM with methotrexate leads to elevated and prolonged levels of methotrexate and its metabolite in the blood which may lead to methotrexate toxicities.
NEXIUM may interfere with CYP2C19 which is a major esomeprazole metabolizing enzyme. Therefore, concurrent administration of esomeprazole and CYP2C19 substrate like diazepam must be avoided.
Drugs like rifampin which are known to induce both CYP2C19 and CYP3A4 if concurrently administered with NEXIUM may reduce the esomeprazole serum level.
Concurrent use of NEXIUM and clopidogrel should be avoided.
Other drugs or herbal preparation including iron supplements, St.John’s wort (it is a plant of which the botanical name is Hypericum perforatum), cilostazol, tacrolimus and erlotinib must be disclosed to the physician while treating with NEXIUM.
Precautions and warnings:
NEXIUM i.e. esomeprazole is likely to get excreted in human breast milk. Therefore a nursing mother should use this drug under strict medical supervision and prescription. If any adverse symptoms are observed then she should contact her physician immediately.
The safety and efficacy of NEXIUM have been proven in children of one to seventeen years old for short-term treatment of GERD. The same is established in infants of one to twelve months old for short-term treatment of erosive esophagitis due to acid-mediated GERD. However, the use of the drug and its safety is not reported for infants less than one-month-old.